Red Blood Cells Store and Release Interleukin-33

Association between nucleated red blood cells in blood and the levels of erythropoietin, interleukin 3, interleukin 6, and interleukin 12p70.

The appearance of nucleated red blood cells (NRBC) in the circulation is associated with a variety of severe diseases, and indicates a relatively poor prognosis. Whether a malfunction of the bone marrow leads to this phenomenon is as unknown as the possible role that cytokines could play in this process. We analyzed erythropoietin, interleukin (IL)-3, IL-6, and IL-12p70 in the blood of 301 pati...

Lactate interferes with ATP release from red blood cells.

Upon exposure to low Po(2), the red blood cells of most species, including humans, release increased amounts of ATP that ultimately serves as a regulator of vascular tone matching oxygen supply with demand. In pathological conditions such as malaria and sepsis, a maldistribution of perfusion exists with its severity often correlated with the extent of elevation of serum lactate frequently in th...

Dynamics of shear-induced ATP release from red blood cells.

Adenosine triphosphate (ATP) is a regulatory molecule for many cell functions, both for intracellular and, perhaps less well known, extracellular functions. An important example of the latter involves red blood cells (RBCs), which help regulate blood pressure by releasing ATP as a vasodilatory signaling molecule in response to the increased shear stress inside arterial constrictions. Although s...

Rediscovering Red Blood Cells: Revealing Their Dynamic Antigens Store and Its Role in Health and Disease

Optimizing Red Blood Cells Consumption Using Markov Decision Process

In healthcare systems, one of the important actions is related to perishable products such as red blood cells (RBCs) units that its consumption management in different periods can contribute greatly to the optimality of the system. In this paper, main goal is to enhance the ability of medical community to organize the RBCs units’ consumption in way to deliver the unit order timely with a focus ...