Recurrent RARB Translocations in Acute Promyelocytic Leukemia Lacking RARA Translocation
نویسندگان
چکیده
منابع مشابه
Acute Promyelocytic Leukemia Lacking the Classic Translocation t(15;17)
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) characterized by the reciprocal translocation t(15;17)(q22;q12) resulting in the fusion gene PML-RARA and an oncoprotein that impairs myeloid differentiation (Arber et al., 2008; de The et al., 1990; Rowley et al., 1977). Morphological and clinical characteristics include hypergranular leukemic promyelocytes, Auer r...
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which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Molecular methods for genomic analyses of variant PML-RARA or other RARA-related chromo-somal translocations in acute promyelocytic leukemia TO THE EDITOR: We read an interesting paper by Palta et al. in a recent issue of the Korean Journal of Hematology tit...
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Acute promyelocytic leukemia (APL) is classically characterized by chromosomal translocation (15;17), resulting in the PML-RARA fusion protein leading to disease. Here, we present a case of a 50-year-old man who presented with signs and symptoms of acute leukemia with concern for APL. Therapy was immediately initiated with all-trans retinoic acid. The morphology of his leukemic blasts was consi...
متن کاملTranslocation (15;17)(q22;q21) not associated with acute promyelocytic leukemia and negative for PML/RARa rearrangement.
Sir, A 44-year old Chinese man presented with a twoweek history of bone pain and myalgia. Complete blood counts showed: hemoglobin (Hb) 6.3 g/dL, white cell count (WBC) 1.1×109/L (blasts 21%), and platelet count (Plt) 159×109/L. The clotting profile was normal. Bone marrow aspiration revealed a morphologic diagnosis of acute myeloid leukemia-M2 (Figure 1A). Cytochemically, the blast cells were ...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2018
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-18-0840