Recurrent Nicolau syndrome associated with subcutaneous glatiramer acetate injection—a case report

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Recurrent Nicolau syndrome associated with subcutaneous glatiramer acetate injection—a case report

BACKGROUND Glatiramer acetate is worldwide used as first line treatment in relapsing remitting multiple sclerosis. Local skin reactions associated with glatiramer acetate are common, however, only isolated cases of severe local injection site reactions known as Nicolau Syndrome have been reported so far. CASE PRESENTATION We describe the case of a recurrent Nicolau Syndrome occurred during lo...

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[Nicolau syndrome after administration of glatiramer acetate].

Local complications associated with glatiramer acetate are frequent, especially at the injection site. The presence of pain, oedema, and local erythema is almost a given in areas where the drug is administered subcutaneously. However, the presence of cutaneous necrosis should alert doctors to the possibility of impairment of underlying vascular structures. Nicolau syndrome or embolia cutis medi...

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Nicolau syndrome: report of a case

Nicolausyndrome or embolia cutis medicamentosa is a rare complication of intramuscular injection of some drugs. This syndrome has been reported after injection of NSAIDS, corticosteroids and antibiotics.Here we report a 16-year-old boy who developed this syndrome after intramuscular injection of benzathine penicillin.

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Reversible alopecia associated with glatiramer acetate.

W e describe a 42-year-old woman with relapsingremitting multiple sclerosis (MS) who developed alopecia while receiving pharmacotherapy with glatiramer acetate (GA). The patient was diagnosed with relapsing-remitting MS in 1998 based on her clinical presentation, positive surrogate disease markers on magnetic resonance imaging, and the presence of multiple oligoclonal bands in her cerebrospinal...

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Glatiramer acetate desensitisation in multiple sclerosis patients - the case report

Methods The 38-year-old woman with a diagnosis of MS was examined from April until July 2013 at the Allergology Unit, Department of Internal Medicine and Gastroenterology. In the absence of specific IgE tests against GA, a basophil activation test (BAT) was performed with a borderline result (GA concentration 1.0 ul/ml with 7.8% activated basophils, stimulation index 2.1). Then followed the GA ...

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ژورنال

عنوان ژورنال: BMC Neurology

سال: 2015

ISSN: 1471-2377

DOI: 10.1186/s12883-015-0504-0