Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing
نویسندگان
چکیده
منابع مشابه
Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing.
Following entry and reverse transcription, the HIV-1 genome is integrated into the host genome. In contrast to productively infected cells, latently infected cells frequently harbor HIV-1 genomes integrated in heterochromatic structures, allowing persistence of transcriptionally silent proviruses. Microglial cells are the main HIV-1 target cells in the central nervous system and constitute an i...
متن کاملLSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing
Microglial cells are the main HIV-1 targets in the central nervous system (CNS) and constitute an important reservoir of latently infected cells. Establishment and persistence of these reservoirs rely on the chromatin structure of the integrated proviruses. We have previously demonstrated that the cellular cofactor CTIP2 forces heterochromatin formation and HIV-1 gene silencing by recruiting HD...
متن کاملCBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency.
The establishment of HIV proviral latency requires the creation of repressive chromatin structures that impair the initiation of transcription and restrict RNAP II elongation. We have found that C-promoter binding factor-1 (CBF-1), a CSL (CBF-1, Su(H) and Lag-1)-type transcription factor and key effector of the Notch signaling pathway, is a remarkably potent and specific inhibitor of the HIV-1 ...
متن کاملNew Nomenclature for Chromatin-Modifying Enzymes
In the last ten years, the importance of chromatin modifications in many aspects of biology has become apparent. Several families of enzymes that modify histones have been identified, the majority of which are conserved throughout evolution. The enormous interest in this field has resulted in a very rapid rate of discovery of new enzymes, but this in turn has lead to a noncoherent nomenclature ...
متن کاملChromatin-modifying enzymes in transcription and cancer
In recent years, our view of how gene expression is controlled has changed dramatically. The discovery of enzymes that modify histones has revealed that transcription is an enzymically driven process. Such modifications can recruit specific proteins and mediate chromatin changes that affect transcription either positively or negatively. Important biological pathways leading to cell proliferatio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2007
ISSN: 0261-4189,1460-2075
DOI: 10.1038/sj.emboj.7601516