منابع مشابه
Responding to and Recovering from Mistakes during Collaboration
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One often hears the lament that medical care in India lags behind that of developed countries. At times, however, one cannot help but feel that in some ways this is a blessing in disguise, because by the time a particular method of treatment gets accepted and adopted in India, we also have knowledge of its various short-comings. If such information is appropriately made use of, it should enable...
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I look back fondly on my years as a postdoctoral fellow (1993–1995) as a period of heightened intellectual growth, clarity and optimism. After 5 years as a PhD student, I was finally set free to explore ideas more of my own creation, to start from scratch a new research project but this time with greater wisdom, experience and vision than was possible as a dazed and confused first-year graduate...
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We re-examine the commonly held view that learning and memory necessarily require potentiation of synapses. A simple neuronal model of self-organized learning with no positive reinforcement is presented. The strongest synapses are selected for propagation of activity. Active synaptic connections are temporarily "tagged" and subsequently depressed if the resulting output turns out to be unsucces...
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D a long discussion of our favorite enzyme mechanisms, Gene Sander advised me that the easiest way to obtain a true picture of the transitory steps of a reaction would be to ‘‘hire a 2-Å postdoc.’’ In the mid-’70s, when this whimsical conversation took place, molecular and structural biology was just beginning to exert an effect on mechanistic enzymology. Whereas the advances of the past 25 yea...
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ژورنال
عنوان ژورنال: Science
سال: 2011
ISSN: 1095-9203
DOI: 10.1126/science.opms.r1100101