Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes
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چکیده
منابع مشابه
Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes
Neurotransmitter release depends on the SNARE complex formed by syntaxin-1, synaptobrevin and SNAP-25, as well as on complexins, which bind to the SNARE complex and play active and inhibitory roles. A crystal structure of a Complexin-I fragment bearing a so-called 'superclamp' mutation bound to a truncated SNARE complex lacking the C-terminus of the synaptobrevin SNARE motif (SNAREΔ60) suggeste...
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ژورنال
عنوان ژورنال: eLife
سال: 2017
ISSN: 2050-084X
DOI: 10.7554/elife.30286