RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR AND NEUTROPHIL PHENOTYPE
نویسندگان
چکیده
منابع مشابه
Effects of recombinant human granulocyte colony-stimulating factor administration on neutrophil phenotype and functions.
BACKGROUND AND OBJECTIVE Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is currently used for treatment of various types of neutropenia, treatment of aplastic anemia, mobilization of peripheral blood progenitor cells. However, rhG-CSF is not only a growth factor for the myeloid lineage, but it also acts as a modulator of neutrophil behavior. The aim of the present review arti...
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Bakground: Granulocyte colony-stimulating factor (G-CSF) is a cytokine that stimulates hematopoiesis and induces proliferation and differentiation of granulocyte progenitor cells as well as production of bone marrow neutrophilic granulocyte colonies. Nowadays, human recombinant G-CSF(hr G-CSF)is used for the treatment of chemotherapy- and radiotherapy-induced neutropenia, and also in patients ...
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C OLONY-STIMULATING FACTORS (CSFs) are required for the survival, proliferation, and differentiation of hematopoietic cells. The granulocyte (G) and granulocyte-monocyte (GM) CSFs stimulate proliferation of committed stem cells for granulocytes and macrophages, and the GM-CSF can also enhance the proliferation of multipotential, erythroid, eosinophil, megakaryocyte, and mast stem cells.’4 Recen...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 1995
ISSN: 0007-1048,1365-2141
DOI: 10.1111/j.1365-2141.1995.tb05334.x