Recombinant expression and downstream processing of the disulfide-rich tumor-targeting peptide chlorotoxin
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چکیده
منابع مشابه
Recombinant expression and downstream processing of the disulfide-rich tumor-targeting peptide chlorotoxin
Chlorotoxin (CTX) is a scorpion-derived disulfide-rich peptide that targets malignant tumors by binding the cell surface matrix metalloproteinase-2 and annexin A2. Various CTXs labeled with functional moieties have shown great potential for tumor diagnosis and treatment. In the present study, we established an efficient approach for preparing mature CTX that may be used for experimental and the...
متن کاملSynthesis and biodistribution study of a chlorotoxin derivative peptide labeled with 131- iodine for tumor therapy
Background: Chlorotoxin is a 36-amino acid peptide found in the venom of the Leiurus quinquestriatus which blocks small-conductance chloride channels. Chlorotoxin binds preferentially to glioma cells that allow development of new methods for the treatment and diagnosis of several types of cancer. Thus chlorotoxin derivative was labeled with 131I for further investigation. Materials and...
متن کاملsynthesis and biodistribution study of a chlorotoxin derivative peptide labeled with 131- iodine for tumor therapy
background: chlorotoxin is a 36-amino acid peptide found in the venom of the leiurus quinquestriatus which blocks small-conductance chloride channels. chlorotoxin binds preferentially to glioma cells that allow development of new methods for the treatment and diagnosis of several types of cancer. thus chlorotoxin derivative was labeled with 131i for further investigation. materials and methods:...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2013
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2013.1234