Reciprocal Spatiotemporally Controlled Apoptosis Regulates Wolffian Duct Cloaca Fusion
نویسندگان
چکیده
منابع مشابه
Reciprocal Spatiotemporally Controlled Apoptosis Regulates Wolffian Duct Cloaca Fusion.
The epithelial Wolffian duct (WD) inserts into the cloaca (primitive bladder) before metanephric kidney development, thereby establishing the initial plumbing for eventual joining of the ureters and bladder. Defects in this process cause common anomalies in the spectrum of congenital anomalies of the kidney and urinary tract (CAKUT). However, developmental, cellular, and molecular mechanisms of...
متن کاملRegulation of Wolffian duct development.
Wolffian ducts (WDs) are the embryonic structures that form the male internal genitalia. These ducts develop in both the male and female embryo. However, in the female they subsequently regress, whereas in the male they are stabilised by testosterone. The WDs then develop into separate but contiguous organs, the epididymis, vas deferens and seminal vesicles. Recently, considerable progress has ...
متن کاملSpatiotemporally controlled single cell sonoporation.
This paper presents unique approaches to enable control and quantification of ultrasound-mediated cell membrane disruption, or sonoporation, at the single-cell level. Ultrasound excitation of microbubbles that were targeted to the plasma membrane of HEK-293 cells generated spatially and temporally controlled membrane disruption with high repeatability. Using whole-cell patch clamp recording com...
متن کاملKaspar Friedrich Wolff ( 1733 - 1794 )
Kaspar Friedrich Wolff is the eponym of four anatomical structures related to the genitourinary system. The Wolffian tubules (aka Kobelt's tubules, named after the nineteenth-century German physician Georg Ludwig Kobelt) are the remnants of the Wolffian duct in the paroophoron, i.e., the broad ligament between the epoophoron and the uterus. The Wolffian body is a name alternatively used for the...
متن کاملNew insights into the role of androgens in wolffian duct stabilization in male and female rodents.
Androgen-mediated wolffian duct (WD) development is programmed between embryonic d 15.5 (e15.5) and 17.5 in male rats, and WD differentiation has been shown to be more susceptible to reduced androgen action than is its initial stabilization. We investigated regulation of these events by comparing fetal WD development at e15.5-postnatal d0 in male and female androgen receptor knockout mice, and ...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2018
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2017040380