Receptors and signals in early thymic selection
نویسندگان
چکیده
منابع مشابه
Thymic selection and autoimmunity
APC = antigen presenting cell; cTEC = thymic cortical epithelial cell; DC = dendritic cell; IκB = inhibitory κB; IL = interleukin; mTEC = medullary thymic epithelial cell; NFκB = nuclear factor κB; NIK = NFκB inhibitory kinase; NOD = non-obese diabetic; NZB = New Zealand black; TLR = tolllike receptor; TNF = tumor necrosis factor; TRAF6 = TNF receptor associated factor 6. Arthritis Research & T...
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Cell division during thymic selection was studied with a system in which purified populations of T cell antigen receptor (TCR)- CD4+8+ (double-positive [DP]) cells and fetal thymic epithelial cells (TEC) were reaggregated in tissue culture. In this system, immature DP cells differentiate into mature single-positive (SP) CD4+8- and CD4-8+ TCRhi cells within 3-4 d, indicative of positive selectio...
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Using a novel system that supports positive selection in vitro, we have investigated the cellular requirements for this process by testing the ability of individual thymic and nonthymic stromal cell types to support the maturation of CD4+CD8+ thymocytes into CD4+ or CD8+ T cells. We show that thymic cortical epithelial cells are unique in their ability to mediate this maturation, and suggest th...
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During their differentiation in the mouse thymus, CD4+8- cells undergo several of the sequential changes observed upon normal activation of mature, peripheral CD4+ lymphocytes. Expression of CD69, an early activation marker, is first observed on a minority of cells at the T cell receptor (TCR)lo/med double-positive stage, is maximal (50-90%) on heat-stable antigen (HSA)hi TCRhi double-positive,...
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The peripheral T cell repertoire is sculpted from prototypic T cells in the thymus bearing randomly generated T cell receptors (TCR) and by a series of developmental and selection steps that remove cells that are unresponsive or overly reactive to self-peptide-MHC complexes. The challenge of understanding how the kinetics of T cell development and the statistics of the selection processes combi...
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ژورنال
عنوان ژورنال: Immunity
سال: 1995
ISSN: 1074-7613
DOI: 10.1016/1074-7613(95)90056-x