Receptor binding site-deleted foot-and-mouth disease (FMD) virus protects cattle from FMD
نویسندگان
چکیده
منابع مشابه
Receptor binding site-deleted foot-and-mouth disease (FMD) virus protects cattle from FMD.
Binding of foot-and-mouth disease virus (FMDV) to cells requires an arginine-glycine-aspartic acid (RGD) sequence in the capsid protein VP1. We have genetically engineered an FMDV in which these three amino acids have been deleted, producing a virus particle which is unable to bind to cells. Cattle vaccinated with these receptor binding site-deleted virions were protected from disease when chal...
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The foot-and-mouth disease virus (FMDV) afflicts livestock in more than 80 countries, limiting food production and global trade. Production of foot-and-mouth disease (FMD) vaccines requires cytosolic expression of the FMDV 3C protease to cleave the P1 polyprotein into mature capsid proteins, but the FMDV 3C protease is toxic to host cells. To identify less-toxic isoforms of the FMDV 3C protease...
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The authors describe a questionnaire survey of foot and mouth disease (FMD) and of FMD control by vaccination in sixty villages in northern Thailand. FMD was found to be common, with 90% of the villages surveyed reporting one or more outbreaks in the five years prior to interview, and 28% of villages reporting outbreaks every year. Outbreaks were more common in the wet season (June to September...
متن کاملComparative immunogenecity of foot and mouth disease virus antigens in FMD-haemorrhagic septicaemia combined vaccine and FMD vaccine alone in buffalo calves.
Humoral immune response was evaluated by monitoring the serum antibody titres and virus specific IgM titres against Foot and Mouth Disease (FMD) virus antigens in serum samples obtained from different groups of calves inoculated with combined vaccine or FMD vaccine alone, on 0, 7, 14, 21, 28, 42 and 56 days post-vaccination (DPV). The cellular immune response was monitored by MTT based lymphopr...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1995
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.69.9.5787-5790.1995