Recent progress in studies on the health benefits of pyrroloquinoline quinone

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Nephrotoxicity of pyrroloquinoline quinone in rats.

When pyrroloquinoline quinone (PQQ) was intraperitoneally injected into rats daily for 4 days at a dose of 11.5 mg/kg body weight/injection, functional and morphologic changes of the kidneys were clearly observed. The most prominent finding was necrotic and degenerative changes of the proximal tubular epithelium as well as hematuria and an elevation of serum creatinine concentration.

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Levels of pyrroloquinoline quinone in various foods.

The levels of free pyrroloquinoline quinone (PQQ) in various foods were examined by the use of gas chromatography-mass spectrometry. PQQ was extracted from the samples, after addition of [U-13C]PQQ as internal standard, with n-butanol and Sep-Pak C18 cartridges. After derivatization of PQQ with phenyltrimethylammonium hydroxide, molecular peaks at m/z 448 and 462 were used for detection of PQQ ...

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The pyrroloquinoline quinone (PQQ)-containing quinoprotein dehydrogenases.

L. (1995) Biochemistry 34, 11080-1 1089 10 Friden, H. and Hederstedt, L. (1990) Mol. Microbiol. 4, 1045-1056 1 1 Nakamura, K., Yamaki, M., Sarada, M., Nakayama, S., Vibat, C. R. T., Gennis, R. B., Nakayashiki, T., Inokuchi, H., Kojima, S. and Kita, K. (1996) J. Biol. Chem. 271, 521-527 12 Hagerhall, C. and Hederstedt, L. (1996) FEBS Lett. 389, 25-31 13 Pennoyer, J. D., Ohnishi, T. and Trumpower...

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ژورنال

عنوان ژورنال: Bioscience, Biotechnology, and Biochemistry

سال: 2016

ISSN: 0916-8451,1347-6947

DOI: 10.1080/09168451.2015.1062715