Recent Progress in Multiple Endocrine Neoplasia Type 2
نویسندگان
چکیده
منابع مشابه
Multiple endocrine neoplasia type 2: recent progress in diagnosis and management.
Multiple endocrine neoplasia type 2 (MEN-2) is an inherited endocrine disorder characterized by the occurrence of malignancies involving the C cells of the thyroid gland, the adrenal medulla, and the parathyroid glands (1). Medullary thyroid carcinoma (MTC) is the key component of MEN-2 and largely determines its mortality (2–6). MEN-2 is caused by germline mutations in the RET proto-oncogene a...
متن کاملMultiple endocrine neoplasia type 2
Multiple Endocrine Neoplasia Type 2 (MEN2) is a rare hereditary complex disorder characterized by the presence of medullary thyroid carcinoma (MTC), unilateral or bilateral pheochromocytoma (PHEO) and other hyperplasia and/or neoplasia of different endocrine tissues within a single patient. MEN2 has been reported in approximately 500 to 1000 families worldwide and the prevalence has been estima...
متن کاملMultiple endocrine neoplasia type I.
An adult woman 43 years old, with Multiple Endocrine Neoplasia type 2A (MEN2A). Clinical diagnosis of MEN2A was made based on the chief complaints of abdominal pain and a lump in the front left side area of neck accompanied with weight loss, from laboratory examination revealed an increased level of plasma levels of calcitonin levels with the result of 6359 pg/ml and 24 hours metanephrine urine...
متن کاملMultiple endocrine neoplasia type 1
Combined clinical and laboratory investigations of MEN-1 have resulted in an increased understanding of this disorder, which may be inherited as an autosomal dominant condition. Defining the features of each disease manifestation in MEN-1 has improved patient management and treatment and has facilitated a screening protocol. Application of the techniques of molecular biology has enabled the ide...
متن کاملMultiple endocrine neoplasia type 1.
Multiple endocrine neoplasia-1 (MEN-1) is an autosomal dominant inherited syndrome that occurs due to inactivating mutations of the MEN1 gene locus, coding for a tumor-suppressor protein, menin. The components of MEN-1 are hyperparathyroidism due to multiple parathyroid adenomas, pancreatic neuroendocrine tumors, and pituitary adenomas, in addition to some less common neoplastic manifestations....
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ژورنال
عنوان ژورنال: Nihon Ika Daigaku Igakkai Zasshi
سال: 2015
ISSN: 1349-8975,1880-2877
DOI: 10.1272/manms.11.6