Recent Patents on Novel P2X7 Receptor Antagonists and their Potential for Reducing Central Nervous System Inflammation
نویسندگان
چکیده
منابع مشابه
Recent Patents on OPC for Central Air-Conditioning System
To achieve the centralized monitoring and integrated management of the central air-conditioning system, taking the characteristics of data communications and control complexity in the air-conditioning system into consideration, and combined with the OPC (OLE(Object Linking and Embedding) for Process Control) technology, an intelligent central airconditioning supervisory system is developed and ...
متن کاملQSAR studies and application of genetic algorithm - multiple linear regressions in prediction of novel p2x7 receptor antagonists’ activity
Quantitative structure-activity relationship (QSAR) models were employed for prediction the activity of P2X7 receptor antagonists. A data set consisted of 50 purine derivatives was utilized in the model construction where 40 and 10 of these compounds were in the training and test sets respectively. A suitable group of calculated molecular descriptors was selected by employing stepwise multiple ...
متن کاملKinin receptor antagonists as potential neuroprotective agents in central nervous system injury.
Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and substance P. These neuropeptides are known to have a potent pro-inflammatory role and can initiate neurogenic inflammation resulting in vasodi...
متن کاملDeath receptor signalling in central nervous system inflammation and demyelination.
Death receptors (DRs) are members of the tumor necrosis factor receptor (TNF-R) superfamily that are characterised by the presence of a conserved intracellular death domain and are able to trigger a signalling pathway leading to apoptosis. Strong evidence suggests that DRs contribute to the pathology of tissue destructive diseases, including multiple sclerosis (MS), the most common inflammatory...
متن کاملThe P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease.
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not exclusively, on immune cells. P2X7 activation results in a number of downstream events, including the release of proinflammatory mediators and cell death and proliferation. As such, P2X7 plays important roles in various inflammatory, immune, neurologic and musculoskeletal disorders. This review focuses on the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Recent Patents on CNS Drug Discovery
سال: 2010
ISSN: 1574-8898
DOI: 10.2174/157488910789753530