Recent and remote retrograde memory deficit in rats with medial entorhinal cortex lesions
نویسندگان
چکیده
منابع مشابه
Spatial and memory circuits in the medial entorhinal cortex
The large capacity of episodic memory is thought to be supported by the emergence of distinct hippocampal cell assemblies for unrelated memories, such that interference is minimized. In large-scale population recordings, the orthogonal nature of hippocampal representations across environments is evident in the complete reorganization of the firing locations of hippocampal place cells. Entorhina...
متن کاملMedial entorhinal cortex lesions only partially disrupt hippocampal place cells and hippocampus-dependent place memory.
The entorhinal cortex provides the primary cortical projections to the hippocampus, a brain structure critical for memory. However, it remains unclear how the precise firing patterns of medial entorhinal cortex (MEC) cells influence hippocampal physiology and hippocampus-dependent behavior. We found that complete bilateral lesions of the MEC resulted in a lower proportion of active hippocampal ...
متن کاملAnterograde and retrograde memory for object discriminations and places in rats with perirhinal cortex lesions.
Three experiments examined the effects of perirhinal cortex lesions on rats' retrograde and anterograde memory for object-discriminations and water-maze place-memory problems. In Experiment 1, rats learned two object-discriminations - the first was learned 2 weeks before surgery and the second 24 h before surgery. Rats with perirhinal cortex lesions displayed mildly impaired retention of both o...
متن کاملRelative contributions of CA3 and medial entorhinal cortex to memory in rats
The hippocampal CA1 field processes spatial information, but the relative importance of intra- vs. extra-hippocampal sources of input into CA1 for spatial behavior is unclear. To characterize the relative roles of these two sources of input, originating in the hippocampal field CA3 and in the medial entorhinal cortex (MEC), we studied effects of discrete neurotoxic lesions of CA3 or MEC on conc...
متن کاملEffects of entorhinal cortex lesions on memory in different tasks.
Lesions of the entorhinal cortex produce retrograde memory impairment in both animals and humans. Here we report the effects of bilateral entorhinal cortex lesions caused by the stereotaxic infusion of N-methyl-D-aspartate (NMDA) in rats at two different moments, before or after the training session, on memory of different tasks: two-way shuttle avoidance, inhibitory avoidance and habituation t...
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ژورنال
عنوان ژورنال: Neurobiology of Learning and Memory
سال: 2018
ISSN: 1074-7427
DOI: 10.1016/j.nlm.2018.07.013