Recent advances in user-friendly computational tools to engineer protein function

Recent advances in computational protein design.

Proteins are the molecules cells primarily rely on for catalysis, recognition, signaling, defense, locomotion, and structural integrity. Engineering proteins for improved function or new applications is a fast-growing segment of biotechnology and biomedicine. Experimental efforts based on the screening of large mutant libraries have led to many successes but they do not provide quantitative des...

Recent Advances In Computational Finance

Recent Advances in Computational Linguistics

ive summarization approaches use information extraction, ontological information, information fusion, and compression. Automatically generated abstracts (abstractive summaries) moves the summarization field from the use of purely extractive methods to the generation of abstracts that contain sentences not found in any of the input documents and can synthesize information across sources. An abst...

From Protein Structure to Function via Computational Tools and Approaches

Proteins are characterized by their amino acid sequence, their structure, and their function. A protein sequence folds into a unique structure, and similar sequences fold into similar structures. There are, however, exceptions to these rules, as detailed below. The important unit of structure is a domain – generally a single stretch of sequence (50–300 amino acids long) that interacts weakly wi...

Recent Advances on Computational Proteomics

In this work we report the recent progresses that have been achieved by our group in the last half decade on the field of computational proteomics. Specifically, we discuss the application of Molecular Dynamics Simulations and Electronic Structure Calculations in drug design, in the clarification of the structural and dynamic properties of proteins and enzymes and in the understanding of the ca...