Recent advances in the mucus-interacting approach for vaginal drug delivery: from mucoadhesive to mucus-penetrating nanoparticles
نویسندگان
چکیده
منابع مشابه
Mucus-penetrating nanoparticles made with "mucoadhesive" poly(vinyl alcohol).
Nanoparticles that readily penetrate mucosal layers are desirable for a variety of biomedical applications. Nevertheless, most nanoparticles tend to be immobilized in mucus via steric and/or adhesive interactions. Contrary to the established opinion that poly(vinyl alcohol) (PVA) is mucoadhesive, we discovered that coating otherwise mucoadhesive nanoparticles with certain partially hydrolyzed P...
متن کاملRecent advances on nano delivery of Helix mucus pharmacologically active components
Bioactive products from snail slime of “Helix” specie have potential applications in preventing and/or treating several human diseases and in cancer diagnosis. However, the poor pharmacokinetics characteristics of these natural compounds limit their use. Nanotechnology offers promising solutions for the enhanced formulation of these molecules through the synthesis of nanosized drug del...
متن کاملRecent advances on nano delivery of Helix mucus pharmacologically active components
Bioactive products from snail slime of “Helix” specie have potential applications in preventing and/or treating several human diseases and in cancer diagnosis. However, the poor pharmacokinetics characteristics of these natural compounds limit their use. Nanotechnology offers promising solutions for the enhanced formulation of these molecules through the synthesis of nanosized drug del...
متن کاملTopical Ocular Drug Delivery to the Back of the Eye by Mucus-Penetrating Particles.
PURPOSE Enhanced drug exposure to the ocular surface typically relies on inclusion of viscosity-enabling agents, whereas delivery to the back of the eye generally focuses on invasive means, such as intraocular injections. Using our novel mucus-penetrating particle (MPP) technology, which rapidly and uniformly coats and penetrates mucosal barriers, we evaluated if such drug formulations could in...
متن کاملrecent advances on nano delivery of helix mucus pharmacologically active components
bioactive products from snail slime of “helix” specie have potential applications in preventing and/or treating several human diseases and in cancer diagnosis. however, the poor pharmacokinetics characteristics of these natural compounds limit their use. nanotechnology offers promising solutions for the enhanced formulation of these molecules through the synthesis of nanosized drug delivery sys...
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ژورنال
عنوان ژورنال: Expert Opinion on Drug Delivery
سال: 2019
ISSN: 1742-5247,1744-7593
DOI: 10.1080/17425247.2019.1645117