Recent Advances in the Hydroxylation of Amino Acids and Its Derivatives

Hydroxy amino acids (HAAs) are of unique value in the chemical and pharmaceutical industry with antiviral, antifungal, antibacterial, anticancer properties. At present, hydroxylated most studied tryptophan, lysine, aspartic acid, leucine, proline, etc., some their derivatives. The hydroxylation is inextricably linked to catalysis various biological enzymes, such as tryptophan hydroxylase, L-pipecolic acid trans-4-hydroxylase, lysine etc. Hydroxylase conspicuously increases variety For manufacture HAAs, high regioselectivity biocatalytic synthesis approach favored over synthesis. Nowadays, widely used method transcribe pathway acids, including catalytic into Corynebacterium glutamicum or Escherichia coli for heterologous expression then produce hydroxyamino acids. In this paper, we systematically reviewed biosynthetic aliphatic, heterocyclic, aromatic introduced basic research application HAAs.