Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function
نویسندگان
چکیده
منابع مشابه
Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function.
INTRODUCTION The bile salt export pump (BSEP/ABCB11), residing in the apical membrane of hepatocyte, mediates the secretion of bile salts into the bile. A range of human diseases is associated with the malfunction of BSEP, including fatal hereditary liver disorders and mild cholestatic conditions. Manifestation of these diseases primarily depends on the mutation type; however, other factors suc...
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ژورنال
عنوان ژورنال: Expert Opinion on Therapeutic Targets
سال: 2015
ISSN: 1472-8222,1744-7631
DOI: 10.1517/14728222.2016.1102889