Recent Advances and Insights into Bromelain Processing, Pharmacokinetics and Therapeutic Uses
نویسندگان
چکیده
Bromelain is a mixture of proteolytic enzymes that extracted primarily from pineapples. It present in almost all the aerial parts plant—the peels, leaves, stems and fruit—although only fruit contain significant amounts. The market-demand for bromelain quickly increasing, especially health sector as it can be used drug and/or nutraceutical. Although complete molecular mechanism has not been fully identified, possesses several properties, including anti-inflammatory, anti-oedema, antithrombotic fibrinolytic, mucolytic, anticancer cicatrizing effects have evaluated clinical trials. However, one main limitations use this supplement varying composition extracts, which leads to heterogeneity results and, therefore, difficulty making evidence-based prescriptions. In fact, different geographic locations, land modes cultivation, well extraction methods, give extracts with activities, depending on plant part used. Additionally, although novel techniques developed improve purification higher yields without loss enzymatic activity, these methods are still expensive challenging. This review will describe state art conventional unconventional discuss advantages strategies. Pharmacokinetic pharmacodynamic profiles applications arisen randomized controlled trials also discussed. Finally, future perspectives presented.
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ژورنال
عنوان ژورنال: Applied sciences
سال: 2021
ISSN: ['2076-3417']
DOI: https://doi.org/10.3390/app11188428