منابع مشابه
Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases.
ADAMTS proteases typically employ some combination of ancillary C-terminal disintegrin-like, thrombospondin-1, cysteine-rich, and spacer domains to bind substrates and facilitate proteolysis by an N-terminal metalloprotease domain. We constructed chimeric proteases and substrates to examine the role of C-terminal domains of ADAMTS13 and ADAMTS5 in the recognition of their physiological cleavage...
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Pluripotent cells are characterized by infinite self-renewal and unrestricted differentiation potential with far-reaching implications in developmental biology and regenerative medicine. Somatic cells can be reprogrammed to a pluripotent state by ectopic expression of defined transcription factors (TFs) such as Oct4, Klf4, Sox2, and c-Myc, generating induced pluripotent stem cells (iPSCs). This...
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The care of patients with chronic disease is one of the most urgent medical challenges in the United States. Chronic illness accounts for most of the demand, expense, and investments in scientific discovery. The well-documented shortcomings in medical quality and safety fall heavily on the shoulders of patients with these conditions (1). Meanwhile, the Medicare program moves steadily toward ins...
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Riemann’s theorems on the rearrangement of absolutely convergent and conditionally convergent series of real numbers are analysed within Bishop-style constructive mathematics. The constructive proof that every rearrangement of an absolutely convergent series has the same sum is relatively straightforward; but the proof that a conditionally convergent series can be rearranged to converge to what...
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A model for diffusion on a cubic lattice with a random distribution of traps is developed. The traps are redistributed at certain time intervals. Such models are useful for describing systems showing dynamic disorder, such as ion-conducting polymers. In the present model the traps are infinite, unlike an earlier version with finite traps. For the infinite trap version a simple analytical calcul...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2008
ISSN: 0961-8368,1469-896X
DOI: 10.1002/pro.5560040203