Rearrangement and polarization

SYNTHESIS AND THERMAL REARRANGEMENT OF OXYGEN HETEROCYCLIC SPIRANS

Thermal rearrangement of spirans (14) and (31) yields the xanthones (16,34) and diphenylrnethane (15, 32), respectively. The structure for xanthone (16), isolated from thermolysis, has been established by reduction to xanthene (20) followed by reoxidation to give xanthone (16). Alternatively, methylation of the diphenylmethane (15) followed by heating with selenium dioxide also yields xant...

Polarization and Polarization Control

Hybridization and Genome Rearrangement

We infer post-hybridization rearrangements in a hybrid genome, given the gene orders on its chromosomes and some knowledge of the two parent genomes. We study this in two biologically and computationally different contexts, genome fusion and interspecific fertilization. Exact algorithms are furnished for some cases, and a heuristic based on the Hannenhalli-Pevzner theory for another.

Genome Rearrangement and Planning

The genome rearrangement problem is to find the most economical explanation for observed differences between the gene orders of two genomes. Such an explanation is provided in terms of events that change the order of genes in a genome. We present a new approach to the genome rearrangement problem, according to which this problem is viewed as the problem of planning rearrangement events that tra...

Genome Rearrangement

The difference between genome rearrangement theory and other approaches to comparative genomics, and indeed most other topics in computational molecular biology, is that it is not directly based on macromolecular sequences, either nucleic acids or proteins. Rather like classical genetics, its building blocks are genes, and the structures of interest are chromosomes, abstracted in terms of the l...