Reanalysis and integration of public microarray datasets reveals novel host genes modulated in leprosy
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چکیده
منابع مشابه
Effective Information Integration from Disparate Microarray Datasets
Although most genes in human DNA have been sequenced, the functional relationships between the genes are not fully understood. The problem with obtaining information about which genes are linked to a specific type of cancer and how these genes are interrelated is an important topic. With the development of DNA microarray and other biological devices, expression levels of thousands of genes can ...
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Voltage-gated calcium channels (VGCCs) are well documented to play roles in cell proliferation, migration, and apoptosis; however, whether VGCCs regulate the onset and progression of cancer is still under investigation. The VGCC family consists of five members, which are L-type, N-type, T-type, R-type and P/Q type. To date, no holistic approach has been used to screen VGCC family genes in diffe...
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Integration microarray and regulation datasets for Chronic Obstructive Pulmonary Disease.
BACKGROUND Pulmonary disease has become one of the major health problems. AIM To investigate the regulation mechanism of Chronic Obstructive Pulmonary Disease (COPD) on gene expression and pathway level. MATERIALS AND METHODS We mapped the differentially expressed genes to a regulation network and pathways, using transcriptome profiles and regulation data. We constructed a TF-target gene re...
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MicroRNAs (miRNAs) are short endogenous RNAs known to post-transcriptionally repress gene expression in animals and plants. A microarray profiling survey revealed the expression patterns of 175 human miRNAs across 24 different human organs. Our results show that proximal pairs of miRNAs are generally coexpressed. In addition, an abrupt transition in the correlation between pairs of expressed mi...
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ژورنال
عنوان ژورنال: Molecular Genetics and Genomics
سال: 2020
ISSN: 1617-4615,1617-4623
DOI: 10.1007/s00438-020-01705-6