Reactive Transport at the Crossroads

Reactive oxygen species at the crossroads of inflammasome and inflammation

Inflammasomes form a crucial part of the innate immune system. These are multi-protein oligomer platforms that are composed of intracellular sensors which are coupled with caspase and interleukin activating systems. Nod-like receptor protein (NLRP) 3, and 6 and NLRC4 and AIM2 are the prominent members of the inflammasome family. Inflammasome activation leads to pyroptosis, a process of programm...

Editorial. At the crossroads.

Colombia at the Crossroads

ove rv i ew The In s ti tute for the Stu dy of Di p l om acy hosted the spring session of the Sch l e s i n ger Work i n g Group on the topic of s tra tegic su rprise in Co l ombi a . Af ter a pre s en t a ti on on four po ten tial scen a rios that may face Co l om bia (see next page ) , S ch l e s i n ger Working Group core mem bers and Co l om bia specialists ex a m i n ed the key factors dri...

Immunology at the crossroads

tell us stories that live in our minds long after we read their words. After 20 years of training some 200 graduate students, I can report some progress in convincing editors that properly trained scientists can do the job of reporting on science for general readers. However—and this is a big however— editors still insist that these scientists must, no matter what their qualification in science...

Scribble at the crossroads

Although proteins involved in determining apical-basal cell polarity have been directly linked to tumorigenesis, their precise roles in this process remain unclear. A recent report in BMC Biology clarifies the signaling pathways that control cell polarity, proliferation and apoptosis downstream of the tumor suppressor and apical-basal polarity determinant Scribble.