Reactive astrocytes express the potassium channel Kir4.1 in active multiple sclerosis lesions
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چکیده
منابع مشابه
Oligodendroglial lineage cells express nuclear p57kip2 in multiple sclerosis lesions.
Impaired remyelination in multiple sclerosis (MS) might be due to the failure of oligodendrocyte precursor cells (OPC) to differentiate into myelinating oligodendrocytes. Animal experimental data have shown that p57kip2 inhibits oligodendroglial differentiation, indicating that this factor could contribute to remyelination failure. This study investigates oligodendroglial p57kip2 expression and...
متن کاملPotassium channel KIR4.1 as an immune target in multiple sclerosis.
BACKGROUND Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. Many findings suggest that the disease has an autoimmune pathogenesis; the target of the immune response is not yet known. METHODS We screened serum IgG from persons with multiple sclerosis to identify antibodies that are capable of binding to brain tissue and observed specific binding...
متن کاملAutoantibodies to Potassium Channel KIR4.1 in Multiple Sclerosis
Journal of Medicine, Srivastava and colleagues reported the presence of antibodies to the inward rectifying potassium channel 4.1 (anti-KIR4.1) in MS (7). The authors observed that purified serum immunoglobulin G (IgG) from MS patients, but not from patients with other neurological diseases, bound to a glial protein in human brain sections. Human brain lysate precipitated with IgG from MS patie...
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Background: The number of patients with Multiple Sclerosis (MS) is increasing in Iran. Studies have shown that high sodium chloride (salt) and low potassium intake are associated with the development of MS. High physiological salt concentrations can lead to the induction of Interleukin-17 (IL-17) accompanied by the excessive generation of helper T-17 cells (Th-17). This cytokine plays a critica...
متن کاملThe Role of Astrocytes in Multiple Sclerosis
The role traditionally assigned to astrocytes in the pathogenesis of multiple sclerosis (MS) lesions has been the formation of the glial scar once inflammation has subsided. Astrocytes are now recognized to be early and highly active players during lesion formation and key for providing peripheral immune cells access to the central nervous system. Here, we review the role of astrocytes in the f...
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ژورنال
عنوان ژورنال: Clinical and Experimental Neuroimmunology
سال: 2013
ISSN: 1759-1961
DOI: 10.1111/cen3.12011