Re: The new macrolide antibiotics: Use them carefully
نویسندگان
چکیده
منابع مشابه
The polyene macrolide antibiotics.
The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.
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Sir: Microbial conversion of antibiotically inactive macrocyclic lactones to active compounds is an important approach in the search for new macrolide antibiotics. Mutational biosynthesis originally proposed by SHIER et al.1) was proved useful also for constructing new macrolide antibiotics and many new derivatives were obtained. However, these were virtually inactive,2-1) or weakly active and ...
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Erythromycin and related macrolide antibiotics have recently enjoyed a resurgence of clinical interest. This is a result of activity against organisms which are becoming more prevalent, particularly in immunocompromised hosts and, in addition, better understanding of the unique tissue penetration properties and potential immunomodulating properties of macrolides. Other features of clinical inte...
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Since 1950, well over fifty macrolides have been derived from various Actinomycetes in screening laboratories located at many corners of the world. Among the most intensely studied macrolides are those produced on a commercial scale (erythromycin, oleandomycin, tylosin, leucomycin and spiramycin) as well as examples of particular historical/scientific importance (Magnamycin, pikromycin, narbomy...
متن کاملMacrolide antibiotics and pulmonary inflammation.
Many clinically effective therapeutic agents can exhibit localized and systemic effects that are manifestly different from their intended primary pharmacological mode of action. Macrolide antibiotics such as erythromycin and its derivatives are no exception. In addition to their antibacterial action, this class of antibiotics exhibits anti-inflammatory activity in a variety of airway diseases s...
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ژورنال
عنوان ژورنال: Paediatrics & Child Health
سال: 1998
ISSN: 1205-7088,1918-1485
DOI: 10.1093/pch/3.4.281