Rdh54/Tid1 inhibits Rad51-Rad54-mediated D-loop formation and limits D-loop length
نویسندگان
چکیده
منابع مشابه
Rad54 functions as a heteroduplex DNA pump modulated by its DNA substrates and Rad51 during D loop formation.
The displacement loop (D loop) is the product of homology search and DNA strand invasion, constituting a central intermediate in homologous recombination (HR). In eukaryotes, the Rad51 DNA strand exchange protein is assisted in D loop formation by the Rad54 motor protein. Curiously, Rad54 also disrupts D loops. How these opposing activities are coordinated toward productive recombination is unk...
متن کاملAssay for human Rad51-mediated DNA displacement loop formation.
Homologous recombination is an important mechanism for the repair of damaged chromosomes, for preventing the demise of damaged replication forks, and for several other aspects of chromosome metabolism and maintenance. The homologous recombination reaction is mediated by the Rad51 recombinase. In the presence of ATP, Rad51 polymerizes on single-stranded DNA (ssDNA) to form a nucleoprotein filame...
متن کاملLength and sequence variation in evening bat D-loop mtDNA.
Length variation in D-loop mitochondrial DNA was observed after amplification with the polymerase chain reaction (PCR) in 28% of 195 evening bats, Nycticeius humeralis, from seven colonies. Nucleotide sequences of PCR products show that this heteroplasmy is characterized by an 81-bp region which is tandemly repeated five to eight times. Southern blots using PCR products as probes on HaeIII geno...
متن کاملTelomeres Do D-Loop–T-Loop
has suggested that telomere-binding proteins provide these functions. Telomere-Binding Proteins. The binding proteins that mediate telomere function come in two flavors: double-stranded DNA-binding proteins and single-stranded DNA end–binding proteins. The best-characterized end-Rarely it seems does a new result emerge, loop around, binding protein is the ␣/ heterodimer protein from Oxy-and bi...
متن کاملTHD Analysis in Closed-Loop Analog PWM Class-D Amplifiers
In this paper, we investigate the parameters affecting Total Harmonic Distortion (THD) and Power Supply Rejection Ratio (PSRR) in PWM Class D Amplifiers (CDAs) on the basis of linear models with feedback. From our mathematical analysis, we show that the THD of a PWM Class D amplifier with feedback can be improved by increasing the gain of the integrator through adding another amplifier at the o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eLife
سال: 2020
ISSN: 2050-084X
DOI: 10.7554/elife.59112