Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma
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چکیده
منابع مشابه
Novel targeting of phospho-cMET overcomes drug resistance and induces antitumor activity in multiple myeloma.
PURPOSE The aim of the study was to verify the hypothesis that the cMet oncogene is implicated in chemio- and novel drug resistance in multiple myeloma. EXPERIMENTAL DESIGN We have evaluated the expression levels of cMET/phospho-cMET (p-cMET) and the activity of the novel selective p-cMET inhibitor (SU11274) in multiple myeloma cells, either sensitive (RPMI-8226 and MM.1S) or resistant (R5 an...
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ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2019
ISSN: 2234-943X
DOI: 10.3389/fonc.2019.00958