Rational Redesign of a Functional Protein Kinase-Substrate Interaction
نویسندگان
چکیده
منابع مشابه
Rational Redesign of a Functional Protein Kinase-Substrate Interaction
Eukaryotic protein kinases typically phosphorylate substrates in the context of specific sequence motifs, contributing to specificity essential for accurate signal transmission. Protein kinases recognize their target sequences through complementary interactions within the active site cleft. As a step toward the construction of orthogonal kinase signaling systems, we have re-engineered the prote...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2017
ISSN: 1554-8929,1554-8937
DOI: 10.1021/acschembio.7b00089