Rational protein design: Combining theory and experiment

Commentary Rational protein design: Combining theory and experiment

The rational design of protein structure and function is rapidly emerging as a powerful approach to test general theories in protein chemistry (1). De novo creation of a protein or an active site requires that all the necessary interactions are provided. The design approach is therefore a way to test the limits of completeness of understanding experimentally. Furthermore, if the experiments are...

Combining theory and experiment in electrocatalysis: Insights into materials design.

Electrocatalysis plays a central role in clean energy conversion, enabling a number of sustainable processes for future technologies. This review discusses design strategies for state-of-the-art heterogeneous electrocatalysts and associated materials for several different electrochemical transformations involving water, hydrogen, and oxygen, using theory as a means to rationalize catalyst perfo...

Rational design of stable lyophilized protein formulations: theory and practice.

Rational Choice Theory: An Overview

It seems easy to accept that rationality involves many features that cannot be summarized in terms of some straightforward formula, such as binary consistency.  However, this recognition does not immediately lead to alternative characterizations that might be regarded as satisfactory, even though the inadequacies of the traditional assumptions of rational behavior standard used in economic theo...

Heterogeneous bids in auctions with rational and boundedly rational bidders—Theory and Experiment

We present results from a series of experiments that allow us to measure overbidding and, in particular, underbidding in first-price auctions. We investigate how the amount of underbidding depends on seemingly innocent parameters of the experimental setup. To structure our data we present and test a theory that introduces constant markdown bidders into a population of fully rational bidders. Wh...