RASSF1A and the rs2073498 Cancer Associated SNP

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RASSF1A and the rs2073498 Cancer Associated SNP

RASSF1A is one of the most frequently inactivated tumor suppressors yet identified in human cancer. It is pro-apoptotic and appears to function as a scaffolding protein that interacts with a variety of other tumor suppressors to modulate their function. It can also complex with the Ras oncoprotein and may serve to integrate pro-growth and pro-death signaling pathways. A SNP has been identified ...

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ژورنال

عنوان ژورنال: Frontiers in Oncology

سال: 2011

ISSN: 2234-943X

DOI: 10.3389/fonc.2011.00054