Rasburicase-induced hemolytic anemia in previously undiagnosed G6PD deficiency

Phenazopyridine-induced hemolytic anemia in a patient with G6PD deficiency.

Unexpected Intravascular Hemolysis and Methemoglobinemia during Treatment for Lymphoma

A patient undergoing chemotherapy for relapsed non Hodgkin lymphoma developed tumor lysis syndrome, hypoxia and the abrupt onset of intravascular hemolysis. A past history of unexplained anemia and the finding of blister cells on peripheral smear led to the suspicion of congenital glucose phosphate dehydrogenase (G6PD) deficiency with intravascular hemolysis induced by the drug rasburicase. G6P...

Rasburicase‐induced methemoglobinemia: case report, literature review, and proposed treatment algorithm

Rasburicase for the treatment of tumor lysis syndrome has been associated with hemolytic anemia and methemoglobinemia, usually in patients with G6PD deficiency. Risks and benefits should be considered prior to use of rasburicase in at-risk patients. Methylene blue will worsen the hemolytic anemia in G6PD deficiency and should be avoided.

Rasburicase causing severe oxidative hemolysis and methemoglobinemia in a patient with previously unrecognized glucose-6-phosphate dehydrogenase deficiency.

Rasburicase is frequently used in tumor lysis syndrome (TLS). Although it is very well tolerated, it can cause severe oxidative hemolytic anemia and methemoglobinemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We report another case of rasburicase-induced methemoglobinemia in a patient with previously unrecognized G6PD deficiency and review the cases of methemoglobine...

Blood smear, a key diagnostic tool in hematology: Lessons from two cases of acute hemolysis in previously undiagnosed G6PD deficiency.

Image 1. Upper panels: Peripheral blood smears of case 1 (A) and 2 (B), showing marked anisopoikilocytosis, with formation of hemi-ghost blister cells (*) and presence of circulating erythroid precursors (insets). Lower panels: Respective values for hemoglobin (Hb), reticulocytes, platelets (PLTs), total white blood cell (WBC) count, bilirubin, lactate dehydrogenase (LDH), and creatinine levels...