Rasburicase (Elitek): A Novel Agent for Tumor Lysis Syndrome
نویسندگان
چکیده
منابع مشابه
Rasburicase (Elitek): a novel agent for tumor lysis syndrome.
The overall incidence of tumor lysis syndrome in adults is not well defined, and its occurrence can be unpredictable. Several strategies are available for the prevention and treatment of tumor lysis syndrome, with rasburicase being the most recent. Rasburicase is a recombinant urate oxidase enzyme approved for use by the Food and Drug Administration in patients who are at risk of developing tum...
متن کاملRasburicase for prevention of hyperuricemia and tumor lysis syndrome.
• Hyperuricemia associated with tumor lysis syndrome is a potentially serious complication most frequently seen during chemotherapy for malignancies with large tumor burden and highly proliferative cells, such as aggressive lymphomas and leukemia.1-3 Hyperuricemia usually occurs in association with other metabolic abnormalities, including hyperphosphatemia, hyperkalemia, hypocalcemia, and azote...
متن کاملThe Efficacy of Single Dose Rasburicase in Prevention or Treatment of Tumor Lysis Syndrome in Children
Background: Tumor lysis syndrome (TLS) is a major metabolic complication in patients with malignancy after initiation of chemotherapy or spontaneously without treatment. The role of Rasburicase (a recombinant urate-oxidase enzyme) in prevention and treatment of TLS has been demonstrated in recent years. We aimed to investigate the efficacy of a single dose of rasburicase in reducing the risk of...
متن کاملRasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout
Hyperuricemia is a feature of several pathologies and requires an appropriate and often early treatment, owing to the severe consequences that it may cause. A rapid and massive raise of uric acid, during tumor lysis syndrome (TLS), and also a lower and chronic hyperuricemia, as in gout, mainly damage the kidney. To prevent or treat these consequences, a new therapeutic option is represented by ...
متن کاملRasburicase for huge hepatocellular carcinoma with tumor lysis syndrome: case report.
OBJECTIVE To report a case of huge hepatocellular carcinoma associated with tumor lysis syndrome and its management. CLINICAL PRESENTATION AND INTERVENTION A 51-year-old hepatitis B carrier visited our clinic with progressive weight loss over recent months. Abdominal ultrasonography and magnetic resonance imaging revealed a huge hepatic mass in a cirrhotic liver, identified as hepatocellular ...
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ژورنال
عنوان ژورنال: Baylor University Medical Center Proceedings
سال: 2005
ISSN: 0899-8280,1525-3252
DOI: 10.1080/08998280.2005.11928082