منابع مشابه
Cellular oncogenes in neoplasia.
In recent years cellular homologues of many viral oncogenes have been identified. As these genes are partially homologous to viral oncogenes and are activated in some tumour cell lines they are termed "proto-oncogenes". In tumour cell lines proto-oncogenes are activated by either quantitative or qualitative changes in gene structure: activation of these genes was originally thought to be a nece...
متن کاملActivated ras Oncogenes in Human Thyroid Cancers1
Human thyroid epithelial (follicular) cells give rise to two malignant tumors—"follicular" carcinomas, which metastasize almost exclusively via the bloodstream, and "papillary" carcinomas, which metastasize predominantly via lymphatics (Williams, E. D. In: W. Duncan (ed.), Recent Results in Cancer Research: Thyroid Cancer, pp. 47-55. Berlin: Springer-Verlag, 1980). We have investigated whethe...
متن کاملOncogenes in Human Cancer: A Review ras
Mutations in codon 12, 13, or 61 of one of the three ras genes, 11-ra.v, k-ra.v, and N-ra.v,convert these genes into active oncogenes. Rapid assays for the detection of these point mutations have been developed recently and used to investigate the role mutated ras genes play in the pathogenesis of human tumors. It appeared that ras gene mutations can be found in a variety of tumor types, althou...
متن کاملras Oncogenes in Human Cancer: A Review1
Mutations in codon 12, 13, or 61 of one of the three ras genes, 11-ra.v, k-ra.v, and N-ra.v,convert these genes into active oncogenes. Rapid assays for the detection of these point mutations have been developed recently and used to investigate the role mutated ras genes play in the pathogenesis of human tumors. It appeared that ras gene mutations can be found in a variety of tumor types, althou...
متن کاملTransforming ras oncogenes and multistage carcinogenesis.
Transforming ras oncogenes and multistage carcinogenesis Few topics have caught the imagination of both clinicians and scientists in the field of cancer research as readily as the recent studies on oncogenes and their role in tumour development. The first identification of transforming genes in human tumours (Der et al., 1982; Parada et al., 1982; Santos et al., 1982) was greeted in certain cir...
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ژورنال
عنوان ژورنال: European Journal of Clinical Investigation
سال: 2008
ISSN: 0014-2972,1365-2362
DOI: 10.1111/j.1365-2362.1990.tb01848.x