منابع مشابه
Getting at MYC through RAS.
The discovery of oncogenes provided insight into the molecular underpinnings of cancer and suggested the promise of novel molecular strategies for cancer treatment as highlighted in this issue by Yaari et al. and by Bishop previously (1, 2). However, only recently have effective drugs that target oncogenes been successfully introduced into the clinical setting. The flagship example of a targete...
متن کاملExtending Egs with Svg for Track Visualization
The Electron Gamma Shower (EGS) Code System at SLAC is designed to simulate the flow of electrons, positrons and photons through matter at a wide range of energies. It has a large user base among the high-energy physics community and is often used as a teaching tool through a Web interface that allows program input and output. Our work aims to improve the user interaction and shower visualizati...
متن کاملPositron Emission Tomography Applications of EGS ’
The use of positron emitters in medical imaging was first suggested by Wrenn and coworkersl, and Sweet’, and the first prototype Positron Emission Tomography (PET) scanner WM built by Brownell and Sweets as shown in Fig. 22.1. A radiopharmaceutical labeled with a positron emitter is distributed within a biological target. The emitted /3+ annihilates with an electron of the surrounding tissue to...
متن کاملThe Ras superfamily at a glance.
The Ras superfamily of small guanosine triphosphatases (GTPases) comprise over 150 human members (Table S1 in supplementary material), with evolutionarily conserved orthologs found in Drosophila, C. elegans, S. cerevisiae, S. pombe, Dictyostelium and plants (Colicelli, 2004). The Ras oncogene proteins are the founding members of this family, which is divided into five major branches on the basi...
متن کاملN-Ras forms dimers at POPC membranes.
Ras is a central regulator of cellular signaling pathways. It is mutated in 20-30% of human tumors. To perform its function, Ras has to be bound to a membrane by a posttranslationally attached lipid anchor. Surprisingly, we identified here dimerization of membrane anchored Ras by combining attenuated total reflectance Fourier transform infrared spectroscopy, biomolecular simulations, and Förste...
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ژورنال
عنوان ژورنال: Astronomy & Geophysics
سال: 1999
ISSN: 1366-8781,1468-4004
DOI: 10.1093/astrog/40.3.3.7-a