Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action
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منابع مشابه
Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action
The mammalian target of rapamycin (mTOR) controls cell growth in response to amino acids and growth factors, in part by regulating p70 S6 kinase alpha (p70 alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor (regulatory associated protein of mTOR) is a 150 kDa mTOR binding protein that is essential for TOR signaling in vivo and also binds 4EBP1 and p70alpha through thei...
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Target of Rapamycin (TOR) signaling is an important regulator in multiple organisms including yeast, plants, and animals. However, the TOR signaling in plants is much less understood as compared to that in yeast and animals. TOR kinase can be efficiently suppressed by rapamycin in the presence of functional FK506 Binding Protein 12 KD (FKBP12) in yeast and animals. In most examined higher plant...
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Louis Pasteur, who discovered microbes cause disease and developed early vaccines, said, “Chance favors the prepared mind.”With this in mind, I joined the physician-scientist MD-PhD training program at Cornell and Rockefeller Universities in 1984. The National Institutes of Health (NIH) launched the medical scientist training program in 1964 to train physician-scientists as ambassadors between ...
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TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of the drug rapamycin used in three different therapeutic areas. The yeast Saccharomyces cerevisiae ha...
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ژورنال
عنوان ژورنال: Cell
سال: 2002
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(02)00833-4