Rapid identification of novel protein families using similarity searches
نویسندگان
چکیده
منابع مشابه
Rapid and sensitive protein similarity searches.
An algorithm was developed which facilitates the search for similarities between newly determined amino acid sequences and sequences already available in databases. Because of the algorithm's efficiency on many microcomputers, sensitive protein database searches may now become a routine procedure for molecular biologists. The method efficiently identifies regions of similar sequence and then sc...
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Protein families often are characterized by conserved sequence patterns or motifs. A researcher frequently wishes to evaluate the significance of a specific pattern within a protein, or to exploit knowledge of known motifs to aid the recognition of greatly diverged but homologous family members. To assist in these efforts, the pattern-hit initiated BLAST (PHI-BLAST) program described here takes...
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Protein similarity searches are a routine job for molecular biologists where a query sequence of amino acids needs to be compared and ranked against an ever-growing database of proteins. All available algorithms in this field can be grouped into two categories – either solving the problem using sequence alignment through dynamic programming, or, employing certain heuristic measures to perform a...
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Searching for similar 3D protein structures is one of the primary processes employed in the field of structural bioinformatics. However, the computational complexity of this process means that it is constantly necessary to search for new methods that can perform such a process faster and more efficiently. Finding molecular substructures that complex protein structures have in common is still a ...
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ژورنال
عنوان ژورنال: F1000Research
سال: 2018
ISSN: 2046-1402
DOI: 10.12688/f1000research.17315.1