Rapid Determination of Log 10 50% Lethal Doses or 50% Infective Doses

Rapid determination of log10 50% lethal doses or 50% infective doses.

A reference table is presented for rapid determination of 50% lethal doses or 50% infective doses after administering 10-fold serial dilutions of toxins, viruses, sera, etc., to six animals per dilution.

Listeria monocytogenes intragastric and intraperitoneal approximate 50% lethal doses for mice are comparable, but death occurs earlier by intragastric feeding.

The intraperitoneal (i.p.) and intragastric (i.g.) mouse approximate 50% lethal dose values (ALD50S) were determined for 15 food and clinical isolates of Listeria monocytogenes. Although all strains gave i.g. ALD50S comparable to or less than their i.p. ALD50S, the i.g. feeding of most strains produced more deaths within the first 3 days of the 6-day test than did i.p. injection. ALD50S ranged ...

Optimal Anti-infective Drug Doses for Children

OPTIMAL ANTI-INFECTIVE DRUG DOSES FOR CHILDREN Anti-infective agents are among the most commonly prescribed drugs in children. What is considered the optimal dose of an anti-infective agent is determined by how the child handles the drug and the resulting drug concentration in the body (pharmacokinetics, PK) as well as by the effect of the drug on the target pathogen (pharmacodynamics, PD). Amo...

2 + 10 > 1 + 50!

Hans Hansson, Christer Norstr om, and Sasikumar Punnekkat M alardalen Real-Time Resear h Centre Department of Computer Engineering Malardalen University, Vaster as, SWEDEN han idt.mdh.se, en mdh.se, spt idt.mdh.se WWW home page: http://www.mrt .mdh.se Abstra t. In traditional design of omputer based systems some e ort, say 1, is spent on the early modeling phases, and some very high e ort, ...

ConnCensus Vol. 50 No. 10