Rapid blood platelet activation: continuous- and quenched-flow versus stopped-flow approaches

Continuous mathematical model of platelet thrombus formation in blood flow

An injury of a blood vessel requires quick repairing of the wound in order to prevent a loss of blood. This is done by the hemostatic system. The key point of its work is the formation of an aggregate from special blood elements, namely, platelets. The construction of a mathematical model of the formation of a thrombocyte aggregate with an adequate representation of its physical, chemical, and ...

Platelet calcium and quenched-flow aggregation kinetics in essential hypertension.

Abnormal platelet function may contribute to the complications of essential hypertension. We have studied the kinetics of platelet aggregation induced by adenosine diphosphate (ADP) or epinephrine, plasma beta-thromboglobulin, and basal, cytosolic, and free calcium, as correlates of platelet function. Fifteen untreated patients with essential hypertension and without detectable atherosclerosis,...

Effect of platelet activation on coronary collateral blood flow.

BACKGROUND The platelet products thromboxane A2 and serotonin have been shown to cause constriction of well-developed coronary collateral vessels. This study was performed to determine whether intravascular platelet activation produced with platelet activating factor (PAF) can cause a decrease in coronary collateral blood flow. METHODS AND RESULTS Collateral vessel growth was induced by embol...

Furrow geometry nnder surge and continuous flow

Newtonian and Non-Newtonian Blood Flow Simulation after Arterial Stenosis- Steady State and Pulsatile Approaches

Arterial stenosis, for example Atherosclerosis, is one of the most serious forms of arterial disease in the formation of which hemodynamic factors play a significant role. In the present study, a 3-D rigid carotid artery with axisymmetric stenosis with 75% reduction in cross-sectional area is considered. Laminar blood flow is assumed to have both Newtonian and non-Newtonian behavior (generalize...