Rapid assay for determination of trimethoprim and sulfamethoxazole levels in serum by spectrofluorometry
نویسندگان
چکیده
منابع مشابه
New rapid assay for nafcillin in serum by spectrofluorometry.
A new, rapid method for measuring serum levels of nafcillin by spectrofluorometry is described. The method involves extraction of 2 ml of acidified serum with n-butyl chloride, subjecting the organic solvent layer to excitation at 340 nm, and measuring the relative intensity of emission fluorescence at 380 nm. An excellent linear correlation exists between serum levels of nafcillin and the rela...
متن کاملDetermination of Sulfamethoxazole and Trimethoprim in Pharmaceuticals by Visible and UV Spectrophotometry
A method for the simultaneous determination of sulfamethoxazole (SMX) and trimethoprim (TMP), based on a direct determination of SMX after diazotization and coupling with 2-naphthol by visible spectrophotometry and an indirect determination of TMP in the UV region by difference was developed. By the suggested procedure, it was possible to analyze SMX and TMP in pharmaceutical preparations witho...
متن کاملDetermination of Sulfamethoxazole and Trimethoprim in Pharmaceuticals by Visible and UV Spectrophotometry
A method for the simultaneous determination of sulfamethoxazole (SMX) and trimethoprim (TMP), based on a direct determination of SMX after diazotization and coupling with 2-naphthol by visible spectrophotometry and an indirect determination of TMP in the UV region by difference was developed. By the suggested procedure, it was possible to analyze SMX and TMP in pharmaceutical preparations witho...
متن کاملdetermination of sulfamethoxazole and trimethoprim in pharmaceuticals by visible and uv spectrophotometry
a method for the simultaneous determination of sulfamethoxazole (smx) and trimethoprim (tmp), based on a direct determination of smx after diazotization and coupling with 2-naphthol by visible spectrophotometry and an indirect determination of tmp in the uv region by difference was developed. by the suggested procedure, it was possible to analyze smx and tmp in pharmaceutical preparations witho...
متن کاملTuberculosis and trimethoprim-sulfamethoxazole.
The sulfonamides were the first drugs with antituberculous effects. Their use was abandoned and basically forgotten with the advent of streptomycin and isoniazid combination treatment. There is a widespread belief, apparently based on testing a single isolate on questionable media, that Mycobacterium tuberculosis is resistant to trimethoprim-sulfamethoxazole (TMP-SMX). We saw a complex immunoco...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1979
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.16.5.579