Rapid 18F-labeling via Pd-catalyzed S-arylation in aqueous medium
نویسندگان
چکیده
منابع مشابه
Pd-catalyzed C3-selective arylation of pyridines with phenyl tosylates.
We have discovered that phenyl tosylates can be used to arylate pyridines at the C3-position using a Pd(OAc)2-1,10-phenanthroline catalyst system. We also discovered that the reaction of 4-methylpyridine with naphthyl tosylates occurred on the methyl group instead of at the C3-position.
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The novel palladium-catalyzed decarboxylative cross-coupling reactions of 2-picolinic acid with aryl and heteroaryl bromides including benzenes, naphthalenes, pyridines and quinolines for C-C bond formation have been successfully achieved.
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Chiral phosphines are essential ligands for asymmetric transitionmetal-catalyzed transformations.1 In 1972, Knowles and co-workers reported the first practical and highly asymmetric hydrogenation using P-stereogenic phosphines,2 yet planar chiral and point chiral phosphines are the most commonly employed ligands today. P-Stereogenic phosphines are less often utilized, in part due to the lack of...
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We herein describe the development of an efficient enantioselective catalytic system that promotes the arylation of secondary silanes. Our method involves treatment of secondary silanes and aryl iodides with a Pd(2)(dba)(3)-asymmetric phosphoramidite ligand system to afford optically active tertiary silanes with good enantioselectivities.
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We report the rapid nucleophilic [(18)F]-radiolabeling of a bodipy dye in aqueous solutions. This radiolabeled dye, whose biodistribution and clearance has been studied in mice, is stable in vivo and can be used as a positron emission tomography/fluorescence dual modality imaging agent.
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2021
ISSN: 1359-7345,1364-548X
DOI: 10.1039/d1cc00745a