منابع مشابه
Rapamycin in preventive (very low) doses
Cancer Biology and Therapy [1], positive effects of low doses of rapamycin on survival of caner-prone HER-2/neu mice have been reported. Inhibitors of the mTOR signaling pathway are already widely employed for anticancer therapy in humans. At the same time, over several last years a substantial body of evidence suggesting an anti-aging effect of at least one mTOR inhibitor, rapamycin, was accum...
متن کاملExtrapolating radiation-induced cancer risks from low doses to very low doses.
There is strong evidence that ionizing radiation increases cancer risks at high doses (e.g., >or=1 Gy), and persuasive, if controversial, epidemiological evidence that cancer risks are increased at low doses ( approximately 10 mGy). Discussed here are the issues related to extrapolating radiation risks from low radiation doses to very low doses (<or=1 mGy) - for which purpose we are forced to r...
متن کاملPaper EXTRAPOLATING RADIATION-INDUCED CANCER RISKS FROM LOW DOSES TO VERY LOW DOSES
There is strong evidence that ionizing radiation increases cancer risks at high doses (e.g., >1 Gy), and persuasive, if controversial, epidemiological evidence that cancer risks are increased at low doses ( 10 mGy). Discussed here are the issues related to extrapolating radiation risks from low radiation doses to very low doses (<1 mGy) — for which purpose we are forced to rely on radiobiologic...
متن کاملIs bigger better? An argument for very low starting doses.
starting treatment of chronic indolent conditions at doses lower than those typically recommended in the product monographs. The approach we recommend is to use a very low dose when starting a new medication if the condition is not life-threatening or producing severe symptoms. Unfortunately, this approach is not used that much in practice. First, we should define “very low dose.” The “start lo...
متن کاملMetabolic Bone Disease in Very Low-Birth-Weight Neonates
Background: Metabolic bone diseases (MBD), including rickets and osteopenia, are important neonatal complications among preterm infants. This study aimed to determine the prevalence and risk factors of MBD in neonates with very low birth weight (VLBW). Methods: This prospective study was conducted on VLBW infants from January 2012 to July 2013. Inclusion criteria were birth weight of ≤1500 g a...
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ژورنال
عنوان ژورنال: Aging
سال: 2014
ISSN: 1945-4589
DOI: 10.18632/aging.100645