منابع مشابه
Photosystem I and Regulatory Proteins for its Biogenesis
Photosystem I (PSI) is a pigment-protein complex located in the thylakoid membrane of cyanobacteria and chloroplasts of algae and higher plants, which functions as a plastocyanin (or cytochrome c6)-ferredoxin oxidoreductase. The reducing potential of ferredoxin is utilized for a variety of biochemical processes such as the reduction of NADP, or the assimilation of nitrate or sulfate. In higher ...
متن کاملRap1 and its effector RIAM are required for lymphocyte trafficking.
Regulation of integrins is critical for lymphocyte adhesion to endothelium and trafficking through secondary lymphoid organs. Inside-out signaling to integrins is mediated by the small GTPase Rap1. Two effectors of Rap1 regulate integrins, RapL and Rap1 interacting adaptor molecule (RIAM). Using mice conditionally deficient in both Rap1a and Rap1b and mice null for RIAM, we show that the Rap1/R...
متن کاملA family of cAMP-binding proteins that directly activate Rap1.
cAMP (3',5' cyclic adenosine monophosphate) is a second messenger that in eukaryotic cells induces physiological responses ranging from growth, differentiation, and gene expression to secretion and neurotransmission. Most of these effects have been attributed to the binding of cAMP to cAMP-dependent protein kinase A (PKA). Here, a family of cAMP-binding proteins that are differentially distribu...
متن کاملSLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1.
SLAT (also known as DEF6) promotes T cell activation and differentiation by regulating NFAT-Ca(2+) signaling. However, its role in TCR-mediated inside-out signaling, which induces integrin activation and T cell adhesion, a central process in T cell immunity and inflammation, has not been explored. Here, we show that SLAT is crucial for TCR-induced adhesion to ICAM-1 and affinity maturation of L...
متن کاملComplement regulatory proteins and autoimmunity.
To discriminate self from non-self is an essential issue in the immune system. Autologous cells are protected against complement-mediated cell injury by the self-recognition mechanism using complement regulatory proteins composed of complement receptor type 1 (CR1, CD35), membrane cofactor protein (MCP, CD46), decay accelerating factor (DAF, CD55) and homologous restriction factor (protectin, C...
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ژورنال
عنوان ژورنال: Small GTPases
سال: 2012
ISSN: 2154-1248,2154-1256
DOI: 10.4161/sgtp.20413