Ranolazine and the Myocardial Demand–Supply Balance
نویسندگان
چکیده
منابع مشابه
Ranolazine and the myocardial demand-supply balance.
Early studies of ranolazine centered on reductions in myocardial oxygen demand produced by partial inhibition of fatty acid oxidation, particularly as free fatty acid levels increase locally during ischemic episodes. More recent studies report that this mechanism is unlikely to be operative at the plasma levels of ranolazine associated with beneficial clinical effect. A reduction in myocardial ...
متن کاملMyocardial hibernation: a delicate balance.
The pathophysiology of myocardial hibernation is characterized as a situation of reduced regional contractile function distal to a coronary artery stenosis that recovers after removal of the coronary stenosis. A subacute "downregulation" of contractile function in response to reduced regional myocardial blood flow exists, which normalizes regional energy and substrate metabolism but does not pe...
متن کاملRanolazine improves autonomic balance in heart failure when added to guideline-driven therapy
BACKGROUND The effect of ranolazine (RAN) on cardiac autonomic balance in congestive heart failure (CHF) was studied. METHODS Fifty-four CHF patients were randomized to (1) open-label RAN (RANCHF) added to usual therapy vs. (2) usual therapy (NORANCHF). Parasympathetic and sympathetic (P&S) measurements were taken at baseline and at 12 months. RESULTS A total of 16/27 (59%) patients in both...
متن کاملA study of the effects of ranolazine using automated quantitative analysis of serial myocardial perfusion images.
OBJECTIVES This study examined the hypothesis that the improvement in myocardial blood flow (MBF) with ranolazine therapy could be detected by serial automated quantitative myocardial perfusion imaging (MPI) in patients with coronary artery disease (CAD) and myocardial ischemia. BACKGROUND Myocardial ischemia enhances late sodium current, which then causes cellular calcium overload leading to...
متن کاملRanolazine prevents INaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension.
AIMS Pulmonary arterial hypertension (PAH) reflects abnormal pulmonary vascular resistance and causes right ventricular (RV) hypertrophy. Enhancement of the late sodium current (INaL) may result from hypertrophic remodelling. The study tests whether: (i) constitutive INaL enhancement may occur as part of PAH-induced myocardial remodelling; (ii) ranolazine (RAN), a clinically available INaL bloc...
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ژورنال
عنوان ژورنال: JACC: Cardiovascular Imaging
سال: 2009
ISSN: 1936-878X
DOI: 10.1016/j.jcmg.2009.09.008