RANKL subcellular trafficking in osteocytes

RANKL From Osteocytes Contributes to Periodontal Bone Loss

Periodontal bone loss results from bacterial infection and the associated host response. The ligand for the receptor activator of NF-κB (RANKL) induces the differentiation of osteoclasts, resulting in periodontal bone loss. The role of osteocytes in periodontal bone loss was investigated in this study. Transgenic mice expressing RANKL under the control of dentin matrix protein 1 (DMP1) were inf...

Contribution of Rankl Regulation to Bone Resorption Induced by Pth Receptor Activation in Osteocytes

Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes.

Osteocyte apoptosis is required to induce intracortical bone remodeling after microdamage in animal models, but how apoptotic osteocytes signal neighboring "bystander" cells to initiate the remodeling process is unknown. Apoptosis has been shown to open pannexin-1 (Panx1) channels to release adenosine diphosphate (ATP) as a "find-me" signal for phagocytic cells. To address whether apoptotic ost...

Alterted GLUT4 subcellular trafficking in primary cultures of rat adipocytes.

Large decreases in insulin-responsive glucose transport occur in rat adipocytes maintained in culture for 20-24 h in the continuous presence of insulin and have altered distributions of GLUT4 and GLUTl as determined by photolabelling with the bis-mannose photolabel ATB-BMPA (2-N-4-( 1 -azi-2,2,2trifluoroethy1)benozyl1,3-bis-(D-mannos-4-yloxy)-2-propylamine) [l]. Furthermore, cells that are chro...

Low Intensity Pulsed Ultrasound Synergistically Modulates Sost and Opg/rankl Ratio in Mlo-y4 Osteocytes in Vitro

Introduction: Bone remodeling is a well coupled biological process of bone resorption and bone formation, which is predominantly regulated by mechanical load. Recent years, osteocytes, the most abundant cell population in bone, have been evidenced to be playing a key role in the modulation of bone remodeling. As a form of mechanical stimulation, low intensity (<30mW/cm2) pulsed ultrasound (LIPU...