RAG1/2 Knockout Pigs with Severe Combined Immunodeficiency

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RAG1/2 knockout pigs with severe combined immunodeficiency.

Pigs share many physiological, biochemical, and anatomical similarities with humans and have emerged as valuable large animal models for biomedical research. Considering the advantages in immune system resemblance, suitable size, and longevity for clinical practical and monitoring purpose, SCID pigs bearing dysfunctional RAG could serve as important experimental tools for regenerative medicine,...

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ژورنال

عنوان ژورنال: The Journal of Immunology

سال: 2014

ISSN: 0022-1767,1550-6606

DOI: 10.4049/jimmunol.1400915