منابع مشابه
RAG - I 1 and RAG - 2 , Adjacent Genes That Synergistically
The vast repertoire of immunoglobulins and T cell receptors is generated, in part, by V(D)J recombination, a series of genomic rearrangements that occur specifically in developing lymphocytes. The recombination activating gene, RAG-1, which is a gene expressed exclusively in maturing lymphoid cells, was previously isolated. RAG-1 inefficiently induced V(D)J recombinase activity when transfected...
متن کاملExpression of human recombination activating genes (RAG-1 and RAG-2) in Hodgkin's disease.
The differentiation status of Sternberg-Reed (SR) cells is still not well defined, primarily because of their scarcity in tumor biopsies of Hodgkin's disease (HD). In this study we have determined the genomic differentiation status of SR cells by quantitation of recombinase activating gene (RAG) expression. RAG genes are selectively transcribed in immature lymphoid cells. In B cells they are si...
متن کاملReexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells.
Recombination activating genes (RAG-1 and RAG-2), involved in V(D)J rearrangement of immunoglobulin genes, have been thought to be expressed only in immature stages of B-cell development. However, RAG-1 and RAG-2 transcripts were found to be reexpressed in mature mouse B cells after culture with interleukin-4 in association with several different co-stimuli. Reexpression was also detected in dr...
متن کاملA Novel Quantitative Fluorescent Reporter Assay for RAG Targets and RAG Activity
Recombination-Activating Genes (RAG) 1 and 2 form the site specific recombinase that mediates V(D)J recombination, a process of DNA editing required for lymphocyte development and responsible for their diverse repertoire of antigen receptors. Mistargeted RAG activity associates with genome alteration and is responsible for various lymphoid tumors. Moreover several non-lymphoid tumors express RA...
متن کاملThe RAG Roman Archaeology : Challenges and Opportunities —
Looking back over the last three decades of Roman archaeology I find it difficult not to be impressed by the huge advances the discipline had made. The quantity of information collected has increased enormously. Romanists have enthusiastically embraced new archaeological technologies, and entire new subject areas landscape archaeology, palaeopathology, and underwater archaeology for instance ha...
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ژورنال
عنوان ژورنال: Nature
سال: 1879
ISSN: 0028-0836,1476-4687
DOI: 10.1038/020456a0