Radical carbonylations using a continuous microflow system

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Radical carbonylations using a continuous microflow system

Radical-based carbonylation reactions of alkyl halides were conducted in a microflow reactor under pressurized carbon monoxide gas. Good to excellent yields of carbonylated products were obtained via radical formylation, carbonylative cyclization and three-component coupling reactions, using tributyltin hydride or TTMSS as a radical mediator.

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An effective method for the synthesis of photochromic diarylethenes based on microflow systems has been developed, and the synthesis of unsymmetrical diarylethenes which is difficult to achieve using conventional macro batch systems, has been accomplished.

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Continuous in situ generation and reaction of phosgene in a microflow system.

Continuous in situ generation of phosgene and its use in acid chloride formation in a microflow system were demonstrated. The acid chloride was subsequently coupled with an amine in high yield without severe epimerization.

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ژورنال

عنوان ژورنال: Beilstein Journal of Organic Chemistry

سال: 2009

ISSN: 1860-5397

DOI: 10.3762/bjoc.5.34