منابع مشابه
Radiation Resistance: Resurrection by Recombination
Adaptation to extreme desiccation has conferred extraordinary radiation resistance on the bacterium Deinococcus radiodurans. How this organism is able to reconstruct a genome shattered by gamma rays has now been revealed.
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The golden era of molecular biology has paved the way for us now to tweak, fix, engineer, or even entirely synthesize genomes at levels and scales never seen before. Sequencing technologies continue to improve at exponential rates and have yielded powerful new insights into organisms of the distant past, as well as those that co-inhabit the planet with us. The era of genomics has ushered in the...
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Previously, we identified beta-galactoside alpha(2,6)-sialyltransferase (ST6Gal I) as a candidate biomarker for ionizing radiation. The expression of ST6Gal I and the level of protein sialylation increased following radiation exposure in a dose-dependent manner. Radiation induced ST6Gal I cleavage and the cleaved form of ST6Gal I was soluble and secreted. Sialylation of integrin beta1, a glycos...
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Adenoviruses are used extensively to deliver genes into mammalian cells, particularly where there is a requirement for high-level expression of transgene products in cultured cells, or for use as recombinant viral vaccines or in gene therapy. In spite of their usefulness, the construction of adenoviral vectors (AdV) is a cumbersome and lengthy process that is not readily amenable to the generat...
متن کاملDisruption of Mouse RAD54 Reduces Ionizing Radiation Resistance and Homologous Recombination
Double-strand DNA break (DSB) repair by homologous recombination occurs through the RAD52 pathway in Saccharomyces cerevisiae. Its biological importance is underscored by the conservation of many RAD52 pathway genes, including RAD54, from fungi to humans. We have analyzed the phenotype of mouse RAD54-/- (mRAD54-/-) cells. Consistent with a DSB repair defect, these cells are sensitive to ionizin...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2007
ISSN: 0960-9822
DOI: 10.1016/j.cub.2006.11.037