Radiation mitigating properties of the lignan component in flaxseed
نویسندگان
چکیده
منابع مشابه
The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage
Plant phenolic compounds are common dietary antioxidants that possess antioxidant and anti-inflammatory properties. Flaxseed (FS) has been reported to be radioprotective in murine models of oxidative lung damage. Flaxseed's protective properties are attributed to its main biphenolic lignan, secoisolariciresinol diglucoside (SDG). SDG is a free radical scavenger, shown in cell free systems to pr...
متن کاملPresence of Caffeic Acid in Flaxseed Lignan Macromolecule
Phenolic compounds were extracted from defatted flaxseeds using ethanol-dioxane (1:1, v/v). The crude extract obtained was purified using Amberlite XAD-16 column chromatography with water and methanol as mobile phases. RP-HPLC and SE-HPLC showed a lignan macromolecule (LM) as a dominant phenolic compound in the purified extract. After the alkaline hydrolysis of LM caffeic acid glucoside (CaAG) ...
متن کاملThe Structure-Activity Relationships of Flaxseed Lignan, Secoisolariciresinol
It is well known that the physiological activities of compounds are affected by their molecular structures. Hence, it is very important for the risk assessment of environmental chemicals such as PCDD and PCDF to evaluate structure-activity relationships (SAR). For precise analysis of SAR, the compounds should be stereoselectively synthesized. In this paper, we evaluated SAR of flaxseed lignan, ...
متن کاملExposure to flaxseed or its lignan component during different developmental stages influences rat mammary gland structures.
Reduction of the highly proliferative terminal end bud (TEB) structures in the developing mammary gland by differentiation to alveolar buds (ABs) and lobules has been suggested to be protective against mammary cancer. Flaxseed is high in alpha-linolenic acid (ALA) and secoisolariciresinol diglycoside (SDG). SDG is the precursor of mammalian lignans, which can affect mammary gland structures. Th...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2013
ISSN: 1471-2407
DOI: 10.1186/1471-2407-13-179